Streptococcal bacteria are among dangerous human pathogens with major prevalence worldwide. A good vaccine against streptococcal bacteria should have epitopes that confer protection from infection by different streptococcal bacteria types. we aimed was to recognize the most immunogenic and conserved epitopes of streptococcal bacteria, which could be a potential candidate for vaccine development...

Streptococcal pharyngitis is among the most common bacterial infections, but the molecular mechanisms involved remain poorly understood. Here we investigate the interactions among three major players in streptococcal pharyngitis: streptococci, plasma, and saliva. We find that saliva activates the plasma coagulation system through both the extrinsic and the intrinsic pathways, entrapping the bac...

  Abstract   Background: The interest in using bacteria as anti- cancer therapeutic agents dates back to the end of the19th century. Some bacteria like Salmonella and Listeria replicate effectively inside malignant cell lines and suppress their growth. The bacterium Streptococcus pyogenes has become medically famous as a flesh-eating pathogen since mid-1980s. It is the causative agent of a life...

Clinical, epidemiological and microbiological studies have conclusively shown that the diagnosis of streptococcal infections based on clinical symptoms always requires microbiological verification. Beta-haemolytic streptococci are the most frequently isolated human pathogens among the representatives of the genus Streptococcus. Nearly all the beta-haemolytic streptococci possess specific carboh...

The role lysogenic bacteriophage play in the pathogenesis of the host bacterium is poorly understood. In a previous study, we found that streptococcal coculture with human pharyngeal cells resulted in the induction of lysogenic bacteriophage as well as the phage-associated streptococcal pyrogenic exotoxin C (SpeC). In this study, we have determined that in addition to SpeC induction, a number o...

A total of 451 strains of gram-positive bacteria were identified with a prototype of the Gram-Positive Identification card used in conjunction with the AutoMicrobic system (Vitek Systems, Inc., Hazelwood, Mo.). Of the species that the Gram-Positive Identification card is capable of identifying, 85% of staphylococcal, 50% of beta-hemolytic group A, B, C, F, and G streptococcal, 91% of group D st...

Streptococcal adhesion, invasion, intracellular trafficking, dissemination and persistence in eukaryotic cells have a variety of implications in the infection pathogenesis. While cell adhesion establishes the initial host contact, adhering bacteria exploit the host cell for their own benefit. Internalisation into the host cell is an essential step for bacterial survival and subsequent dissemina...

Streptococcus spp. are gram-positive bacteria and common human pathogens commensals, causing diseases of various organs in children adults. They etiological factors scarlet fever, pharyngitis, tonsillitis, pneumonia, endocarditis, erysipelas, impetigo, meningitis, necrotising fasciitis, sepsis, among others. The post-streptococcal syndrome is a presumed autoimmune condition that has been associ...

Acute pericarditis, or inflammation of the pericardial sac, is a clinical condition which can often be attributed to variety underlying etiologies, including infection, autoimmune disease, trauma, and malignancy. While viral infections are commonly implicated in etiology bacteria known associated with pericarditis include staphylococcus species, streptococcal tuberculosis, children, Haemophilus...